License, Collaboration and Other Significant Agreements - Deferred Revenues Balance (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred Revenue:
Short-term deferred revenue	$ 20,906	$ 15,214
Long-Term	21,474	$ 25,345
Total	42,380
Otsuka Pharmaceutical Co. Ltd. | Otsuka U.S. Agreement
Deferred Revenue:
Short-term deferred revenue	7,970
Long-Term	12,402
Total	20,372
Otsuka Pharmaceutical Co. Ltd. | Otsuka International Agreement
Deferred Revenue:
Short-term deferred revenue	5,467
Long-Term	4,393
Total	9,860
MTPC | MTPC
Deferred Revenue:
Short-term deferred revenue	7,469
Long-Term	0
Total	7,469
Vifor Pharma
Deferred Revenue:
Short-term deferred revenue	0
Long-Term	4,679
Total	$ 4,679