Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Total revenues	$ 213,578	$ 295,307	$ 335,001
Cost of goods sold:
Product	117,352	148,866	108,935
Amortization of intangibles	36,042	31,515	36,401
Impairment of intangible asset	0	115,527	0
Total cost of goods sold	153,394	295,908	145,336
Operating expenses:
Research and development	147,852	218,485	322,969
Selling, general and administrative	174,161	153,947	149,455
License expense	3,489	3,409	3,529
Total operating expenses	325,502	375,841	475,953
Operating loss	(265,318)	(376,442)	(286,288)
Other income (expense):
Interest income (expense)	(19,936)	(8,871)	792
Other income (expense)	2,414	1,856	(794)
Net loss before income taxes	(282,840)	(383,457)	(286,290)
Benefit from income taxes	0	0	(6,631)
Net loss	$ (282,840)	$ (383,457)	$ (279,659)
Net loss per share - basic (in dollars per share)	$ (1.70)	$ (2.77)	$ (2.36)
Net loss per share - diluted (in dollars per share)	$ (1.70)	$ (2.77)	$ (2.36)
Weighted-average number of common shares - basic (in shares)	165,949,695	138,463,152	118,395,919
Weighted-average number of common shares - diluted (in shares)	165,949,695	138,463,152	118,395,919
Comprehensive loss:
Net loss	$ (282,840)	$ (383,457)	$ (279,659)
Other comprehensive gain - unrealized gain on securities	(7)	13	261
Total comprehensive loss	(282,847)	(383,444)	(279,398)
Product revenue, net
Revenues:
Total revenues	142,216	128,901	111,119
License, collaboration and other revenue
Revenues:
Total revenues	$ 71,362	$ 166,406	$ 223,882