License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) - USD ($) $ in Thousands	12 Months Ended			24 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2021
License, Collaboration and Other Revenue:
Total revenues	$ 213,578	$ 295,307	$ 335,001
Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	800	400		$ 1,200
License, collaboration and other revenue
License, Collaboration and Other Revenue:
Total revenues	71,362	166,406	223,882
License, collaboration and other revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	12,438	15,405	10,000
License, collaboration and other revenue | Otsuka Pharmaceutical Co. Ltd. | Otsuka U.S. Agreement
License, Collaboration and Other Revenue:
Total revenues	36,588	93,446	131,314
License, collaboration and other revenue | Otsuka Pharmaceutical Co. Ltd. | Otsuka International Agreement
License, Collaboration and Other Revenue:
Total revenues	16,449	45,451	75,614
License, collaboration and other revenue | Total Proportional Performance Revenue
License, Collaboration and Other Revenue:
Total revenues	65,475	154,302	216,928
License, collaboration and other revenue | JT and Torii
License, Collaboration and Other Revenue:
Total revenues	5,814	5,681	5,882
License, collaboration and other revenue | Other Revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	$ 73	$ 6,423	$ 1,072