Product Revenue, Net - Summary of Product Revenue Allowance and Reserve Categories (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
SEC Schedule, 12-09, Movement in Valuation Allowances and Reserves [Roll Forward]
Beginning balance	$ 41,363	$ 31,543	$ 23,737
Provisions related to sales in current year	150,908	167,269	120,696
Adjustments related to prior year sales	(1,791)	377	1,149
Credits/payments made	(162,102)	(157,826)	(114,039)
Ending balance	28,378	41,363	31,543
Chargebacks and Discounts
SEC Schedule, 12-09, Movement in Valuation Allowances and Reserves [Roll Forward]
Beginning balance	802	738	516
Provisions related to sales in current year	11,759	10,559	7,822
Adjustments related to prior year sales	(1)	0	0
Credits/payments made	(11,282)	(10,495)	(7,600)
Ending balance	1,278	802	738
Rebates, Fees and other Deductions
SEC Schedule, 12-09, Movement in Valuation Allowances and Reserves [Roll Forward]
Beginning balance	39,912	30,552	22,861
Provisions related to sales in current year	133,297	149,472	110,866
Adjustments related to prior year sales	(1,790)	377	1,149
Credits/payments made	(144,794)	(140,489)	(104,324)
Ending balance	26,625	39,912	30,552
Returns
SEC Schedule, 12-09, Movement in Valuation Allowances and Reserves [Roll Forward]
Beginning balance	649	253	360
Provisions related to sales in current year	5,852	7,238	2,008
Adjustments related to prior year sales	0	0	0
Credits/payments made	(6,026)	(6,842)	(2,115)
Ending balance	$ 475	$ 649	$ 253