Product Revenue, Net - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Disaggregation of Revenue [Line Items]
Total revenues	$ 213,578	$ 295,307	$ 335,001
Product revenue, net
Disaggregation of Revenue [Line Items]
Total revenues	142,216	128,901	$ 111,119
Accounts receivable, net	$ 24,600	$ 21,900