Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 149,800	$ 228,698
Available for sale securities	0	39,992
Inventory	38,195	61,017
Accounts receivable, net	50,875	26,853
Prepaid expenses and other current assets	33,140	14,877
Total current assets	272,010	371,437
Property and equipment, net	6,754	8,622
Operating lease assets	33,852	26,876
Goodwill	55,053	55,053
Other intangible assets, net	108,127	144,170
Other assets	49,754	37,981
Total assets	525,550	644,139
Current liabilities:
Accounts payable	33,588	41,308
Accrued expenses and other current liabilities	104,456	130,624
Short-term deferred revenue	20,906	15,214
Current portion of long-term debt	97,543	0
Total current liabilities	256,493	187,146
Deferred revenue, net of current portion	21,474	25,345
Operating lease liabilities, net of current portion	33,703	24,621
Derivative liability	1,820	2,420
Long-term debt, net	0	96,378
Liability related to sale of future royalties, net	53,079	0
Other non-current liabilities	82,525	60,611
Total liabilities	449,094	396,521
Commitments and contingencies (Note 16)
Stockholders' equity:
Preferred stock $0.00001 par value, 25,000,000 shares authorized at December 31, 2021 and 2020; 0 shares issued and outstanding at December 31, 2021 and 2020	0	0
Common stock: $0.00001 par value; 350,000,000 shares authorized at December 31, 2021 and 2020, respectively; 177,000,963 and 148,074,085 shares issued and outstanding at December 31, 2021 and 2020, respectively	1	1
Additional paid-in capital	1,536,800	1,425,115
Accumulated other comprehensive gain	6	13
Accumulated deficit	(1,460,351)	(1,177,511)
Total stockholders' equity	76,456	247,618
Total liabilities and stockholders' equity	$ 525,550	$ 644,139