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Accrued Expenses
 12 Months Ended
Dec. 31, 2021
Payables and Accruals [Abstract]  
Accrued Expenses Accrued Expenses
Accrued expenses are as follows:
 December 31, 2021December 31, 2020
 (in thousands)
Product revenue allowances$26,624 $38,049 
Accrued clinical14,036 28,986 
Amounts due to collaboration partners22,654 17,977 
Otsuka PRV contribution— 10,000 
Accrued payroll and related15,863 14,899 
Lease liability4,802 5,286 
Royalties3,472 2,998 
Professional fees1,899 3,271 
Accrued commercial manufacturing3,843 514 
Accrued other11,263 8,644 
Total accrued expenses$104,456 $130,624