Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Product revenue allowances	$ 44,235	$ 38,049
Accrued clinical	19,249	28,986
Collaborative arrangement accrued liability	27,375	17,977
Otsuka PRV contribution	10,000	10,000
Accrued payroll and related	12,834	14,899
Lease liability	$ 5,723	$ 5,286
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Total accrued expenses	Total accrued expenses
Royalties	$ 3,022	$ 2,998
Professional fees	9,126	3,271
Accrued commercial manufacturing	1,682	514
Accrued other	11,458	8,644
Total accrued expenses	$ 144,704	$ 130,624