Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenues:
Total revenues	$ 48,756	$ 59,988	$ 153,973	$ 238,608
Cost of goods sold:
Product	6,933	24,239	76,012	92,840
Amortization of intangibles	9,011	6,106	27,032	24,307
Impairment of intangible asset	0	0	0	115,527
Total cost of goods sold	15,944	30,345	103,044	232,674
Operating expenses:
Research and development	40,471	46,857	118,296	180,907
Selling, general and administrative	46,357	40,171	129,336	113,636
License expense	870	710	2,460	2,430
Total operating expenses	87,698	87,738	250,092	296,973
Operating loss	(54,886)	(58,095)	(199,163)	(291,039)
Other income (expense):
Interest expense	(5,085)	(2,274)	(14,853)	(6,554)
Other income	427	410	1,854	1,136
Net loss	$ (59,544)	$ (59,959)	$ (212,162)	$ (296,457)
Net loss per share - basic (in dollars per share)	$ (0.34)	$ (0.42)	$ (1.30)	$ (2.18)
Net loss per share - diluted (in dollars per share)	$ (0.34)	$ (0.42)	$ (1.30)	$ (2.18)
Weighted-average number of common shares - basic (in shares)	173,782,151	143,314,729	163,050,769	136,230,889
Weighted-average number of common shares - diluted (in shares)	173,782,151	143,314,729	163,050,769	136,230,889
Comprehensive loss:
Net loss	$ (59,544)	$ (59,959)	$ (212,162)	$ (296,457)
Other comprehensive gain (loss) - unrealized gain (loss) on debt securities	0	15	(7)	6
Total comprehensive loss	(59,544)	(59,944)	(212,169)	(296,451)
Product revenue, net
Revenues:
Total revenues	36,753	34,392	100,120	94,297
License, collaboration and other revenue
Revenues:
Total revenues	$ 12,003	$ 25,596	$ 53,853	$ 144,311