License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
License, Collaboration and Other Revenue:
Total revenues	$ 48,756	$ 59,988	$ 153,973	$ 238,608
Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues			900
License, collaboration and other revenue
License, Collaboration and Other Revenue:
Total revenues	12,003	25,596	53,853	144,311
License, collaboration and other revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	2,555	373	7,167	15,373
License, collaboration and other revenue | Otsuka Pharmaceutical Company. Ltd. | Otsuka U.S. Agreement
License, Collaboration and Other Revenue:
Total revenues	6,144	16,256	28,988	80,721
License, collaboration and other revenue | Otsuka Pharmaceutical Company. Ltd. | Otsuka International Agreement
License, Collaboration and Other Revenue:
Total revenues	1,860	7,243	13,532	39,445
License, collaboration and other revenue | Total Proportional Performance Revenue
License, Collaboration and Other Revenue:
Total revenues	10,559	23,872	49,687	135,539
License, collaboration and other revenue | JT and Torii
License, Collaboration and Other Revenue:
Total revenues	1,444	1,183	4,093	4,049
License, collaboration and other revenue | MTPC Other Revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	$ 0	$ 541	$ 73	$ 4,723