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Accrued Expenses
 9 Months Ended
Sep. 30, 2021
Payables and Accruals [Abstract]  
Accrued Expenses Accrued Expenses
Accrued expenses as of September 30, 2021 and December 31, 2020 are as follows:
 
 September 30, 2021December 31, 2020
 (in thousands)
Product revenue allowances$44,235 $38,049 
Accrued clinical19,249 28,986 
Amounts due to collaboration partners27,375 17,977 
Otsuka PRV contribution10,000 10,000 
Accrued payroll and related12,834 14,899 
Lease liability5,723 5,286 
Royalties3,022 2,998 
Professional fees9,126 3,271 
Accrued commercial manufacturing1,682 514 
Accrued other11,458 8,644 
Total accrued expenses$144,704 $130,624