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Quarterly Results (unaudited)
 12 Months Ended
Dec. 31, 2020
Quarterly Financial Information Disclosure [Abstract]  
Quarterly Results (unaudited) Quarterly Results (unaudited)
 Three Months Ended
March 31, 2020June 30, 2020September 30, 2020December 31, 2020
(in thousands, except per share data)
(unaudited)
Product revenue, net$29,209 $30,696 $34,392 $34,604 
License, collaboration and other revenue$59,269 $59,446 $25,596 $22,095 
Cost of goods sold$27,713 $174,616 $30,345 $63,234 
Operating expenses$119,890 $89,345 $87,738 $78,868 
Loss from operations$(59,125)$(173,819)$(58,095)$(85,403)
Other expense, net$(1,622)$(1,932)$(1,864)$(1,597)
Benefit for income taxes$— $— $— $— 
Net loss$(60,747)$(175,751)$(59,959)$(87,000)
Net loss per share:
basic and diluted$(0.47)$(1.28)$(0.42)$(0.60)
Weighted-average number of common shares:
basic and diluted128,395,163 136,906,968 143,314,729 145,111,415 
 Three Months Ended
 March 31, 2019June 30, 2019September 30, 2019December 31, 2019
 (in thousands, except per share data)
(unaudited)
Product revenue, net$23,111 $29,089 $30,004 $28,915 
License, collaboration and other revenue$49,555 $71,714 $61,973 $40,640 
Cost of goods sold$31,257 $37,669 $38,263 $38,147 
Operating expenses$117,378 $122,657 $109,619 $126,299 
Loss from operations$(75,969)$(59,523)$(55,905)$(94,891)
Other income (expense), net$791 $508 $43 $(1,344)
Benefit for income taxes$(2,757)$(845)$(1,277)$(1,752)
Net loss$(72,421)$(58,170)$(54,585)$(94,483)
Net loss per share:
basic and diluted$(0.62)$(0.49)$(0.46)$(0.79)
Weighted-average number of common shares:
basic and diluted117,063,352 118,268,832 118,863,063 119,358,081