Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Revenues:
Total revenues	$ 59,988	$ 91,977	$ 238,608	$ 265,446
Cost of goods sold:
Product	24,239	29,162	92,840	79,888
Amortization of intangibles	6,106	9,101	24,307	27,301
Impairment of intangible asset	0	0	115,527	0
Total cost of goods sold	30,345	38,263	232,674	107,189
Operating expenses:
Research and development	46,857	74,512	180,907	242,557
Selling, general and administrative	40,171	34,178	113,636	104,537
License expense	710	929	2,430	2,560
Total operating expenses	87,738	109,619	296,973	349,654
Operating loss	(58,095)	(55,905)	(291,039)	(191,397)
Other income (expense):
Interest income (expense)	(2,274)	228	(6,554)	1,582
Other income (expense)	410	(185)	1,136	(240)
Net loss before income taxes	(59,959)	(55,862)	(296,457)	(190,055)
Benefit from income taxes	0	(1,277)	0	(4,879)
Net loss	$ (59,959)	$ (54,585)	$ (296,457)	$ (185,176)
Net loss per share - basic and diluted (in dollars per share)	$ (0.42)	$ (0.46)	$ (2.18)	$ (1.57)
Weighted-average number of common shares - basic and diluted (in shares)	143,314,729	118,863,063	136,230,889	118,071,674
Comprehensive loss:
Net loss	$ (59,959)	$ (54,585)	$ (296,457)	$ (185,176)
Other comprehensive gain (loss) - unrealized gain (loss) on debt securities	15	(17)	6	267
Total comprehensive loss	(59,944)	(54,602)	(296,451)	(184,909)
Product revenue, net
Revenues:
Total revenues	34,392	30,004	94,297	82,204
License, collaboration and other revenue
Revenues:
Total revenues	$ 25,596	$ 61,973	$ 144,311	$ 183,242