Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019
Revenues:
Total revenues	$ 90,142	$ 100,803	$ 178,620	$ 173,469
Cost of goods sold:
Product	49,988	28,569	68,601	50,726
Amortization of intangibles	9,101	9,100	18,201	18,200
Impairment of intangible asset	115,527	0	115,527	0
Total cost of goods sold	174,616	37,669	202,329	68,926
Operating expenses:
Research and development	52,819	85,694	134,050	168,045
Selling, general and administrative	35,482	36,068	73,465	70,359
License expense	1,044	895	1,720	1,631
Total operating expenses	89,345	122,657	209,235	240,035
Operating loss	(173,819)	(59,523)	(232,944)	(135,492)
Other income (expense):
Interest income (expense)	(2,308)	485	(4,280)	1,354
Other income (expense)	376	23	726	(55)
Net loss before income taxes	(175,751)	(59,015)	(236,498)	(134,193)
Benefit from income taxes	0	(845)	0	(3,602)
Net loss	$ (175,751)	$ (58,170)	$ (236,498)	$ (130,591)
Net loss per share - basic and diluted (in dollars per share)	$ (1.28)	$ (0.49)	$ (1.78)	$ (1.11)
Weighted-average number of common shares - basic and diluted (in shares)	136,906,968	118,268,832	132,651,066	117,669,422
Comprehensive loss:
Net loss	$ (175,751)	$ (58,170)	$ (236,498)	$ (130,591)
Other comprehensive gain (loss) - unrealized gain (loss) on debt securities	(9)	59	(9)	284
Total comprehensive loss	(175,760)	(58,111)	(236,507)	(130,307)
Product revenue, net
Revenues:
Total revenues	30,696	29,089	59,905	52,200
License, collaboration and other revenue
Revenues:
Total revenues	$ 59,446	$ 71,714	$ 118,715	$ 121,269