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Accrued Expenses
 6 Months Ended
Jun. 30, 2020
Payables and Accruals [Abstract]  
Accrued Expenses Accrued Expenses
Accrued expenses as of June 30, 2020 and December 31, 2019 are as follows:
 
 June 30, 2020December 31, 2019
 (in thousands)
Accrued clinical$63,046  $61,815  
Product revenue allowances40,975  30,552  
Accrued payroll9,486  12,604  
MTPC - Supply of Validation Drug Product6,441  —  
Lease liability5,206  4,989  
Royalties2,815  2,713  
Accrued commercial manufacturing2,676  2,680  
Professional fees1,747  3,444  
Accrued severance712  725  
Accrued other9,728  9,549  
Total accrued expenses$142,832  $129,071