License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	$ 88,478	$ 72,666
License, Collaboration and Other Revenue
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	59,269	49,555
License, Collaboration and Other Revenue | Otsuka Pharmaceutical Company. Ltd. | Development and Commercialize United States Collaboration and License Agreement
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	38,577	26,223
License, Collaboration and Other Revenue | Otsuka Pharmaceutical Company. Ltd. | Development and Commercialize International Collaboration and License Agreement
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	19,370	21,956
License, Collaboration and Other Revenue | Mitsubishi Tanabe Pharma Corporation and Otsuka Pharmaceutical Company Limited
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	57,947	48,179
License, Collaboration and Other Revenue | Japan Tobacco Incorporation and Torii Pharmaceutical Company Limited
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	1,126	1,228
License, Collaboration and Other Revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	0	0
License, Collaboration and Other Revenue | Other Revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
License, Collaboration and Other Revenue	$ 196	$ 148