Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues:
Total revenues	$ 88,478	$ 72,666
Cost of goods sold:
Product	$ 18,613	$ 22,157
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember
Amortization of intangibles	$ 9,100	$ 9,100
Total cost of goods sold	27,713	31,257
Operating expenses:
Research and development	81,231	82,351
Selling, general and administrative	37,983	34,291
License expense	676	736
Total operating expenses	119,890	117,378
Operating loss	(59,125)	(75,969)
Other income (expense):
Interest income (expense)	(1,972)	869
Other income (expense)	350	(78)
Net loss before income taxes	(60,747)	(75,178)
Benefit from income taxes		(2,757)
Net loss	$ (60,747)	$ (72,421)
Net loss per share - basic and diluted	$ (0.47)	$ (0.62)
Weighted-average number of common shares - basic and diluted	128,395,163	117,063,352
Comprehensive loss:
Net loss	$ (60,747)	$ (72,421)
Other comprehensive gain - unrealized gain on debt securities		225
Total comprehensive loss	(60,747)	(72,196)
Product Revenue, Net
Revenues:
Total revenues	29,209	23,111
License, Collaboration and Other Revenue
Revenues:
Total revenues	$ 59,269	$ 49,555