Accrued Expenses

3 Months Ended

Mar. 31, 2020

Payables And Accruals [Abstract]

Accrued Expenses

10. Accrued Expenses

Accrued expenses as of March 31, 2020 and December 31, 2019 are as follows:

	March 31, 2020		December 31, 2019
	(in thousands)
Accrued clinical	$	54,581	$	61,815
Product revenue allowances		31,225		30,552
Accrued payroll		7,727		12,604
MTPC - Supply of Validation Drug Product		6,441		—
Lease liability		5,096		4,989
Professional fees		3,949		3,444
Accrued commercial manufacturing		2,694		2,680
Royalties		2,459		2,713
Accrued severance		452		725
Accrued other		10,263		9,549
Total accrued expenses	$	124,887	$	129,071