Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenues:
Total revenues	$ 91,977	$ 53,169	$ 265,446	$ 147,892
Cost of goods sold:
Product	$ 29,162		$ 79,888
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember	us-gaap:ProductMember
Amortization of intangibles	$ 9,101		$ 27,301
Total cost of goods sold	38,263		107,189
Operating expenses:
Research and development	74,512	$ 70,634	242,557	$ 203,955
Selling, general and administrative	34,178	10,378	104,537	31,940
License expense	929		2,560
Total operating expenses	109,619	81,012	349,654	235,895
Operating loss	(55,905)	(27,843)	(191,397)	(88,003)
Other income:
Interest income	228	1,780	1,582	4,417
Other income (expense)	(185)	16	(240)	52
Net loss before income taxes	(55,862)	(26,047)	(190,055)	(83,534)
Benefit from income taxes	(1,277)		(4,879)
Net loss	$ (54,585)	$ (26,047)	$ (185,176)	$ (83,534)
Net loss per share - basic and diluted	$ (0.46)	$ (0.46)	$ (1.57)	$ (1.54)
Weighted-average number of common shares - basic and diluted	118,863,063	57,027,598	118,071,674	54,207,973
Comprehensive loss:
Net loss	$ (54,585)	$ (26,047)	$ (185,176)	$ (83,534)
Other comprehensive gain (loss) - unrealized gain (loss) on debt securities	(17)	50	267	33
Total comprehensive loss	(54,602)	(25,997)	(184,909)	(83,501)
Product Revenue, Net
Revenues:
Total revenues	30,004		82,204
License, Collaboration and Other Revenue
Revenues:
Total revenues	$ 61,973	$ 53,169	$ 183,242	$ 147,892