Accrued Expenses

9 Months Ended

Sep. 30, 2019

Payables And Accruals [Abstract]

Accrued Expenses

10. Accrued Expenses

Accrued expenses as of September 30, 2019 and December 31, 2018 are as follows:

	September 30, 2019		December 31, 2018
	(in thousands)
Accrued clinical expenses	$	66,194	$	71,881
Product revenue allowances		28,408		22,861
Accrued bonus		7,740		9,537
Lease liability		4,884		—
Accrued commercial manufacturing		3,352		6,383
Royalties		2,697		2,430
Professional fees		2,393		2,367
Accrued payroll		1,208		2,255
Accrued vacation		926		1,088
Accrued severance		79		3,962
Merger costs		—		16,071
Accrued other		8,763		12,082
Total accrued expenses	$	126,644	$	150,917