Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2019	Mar. 31, 2018
Revenues:
Total revenues	$ 72,666	$ 45,930
Cost of goods sold:
Product	$ 22,157
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember
Amortization of intangibles	$ 9,100
Total cost of goods sold	31,257
Operating expenses:
Research and development	82,351	$ 61,404
Selling, general and administrative	34,291	9,024
License expense	736
Total operating expenses	117,378	70,428
Operating loss	(75,969)	(24,498)
Other income:
Interest income	869	1,076
Other income (expense)	(78)	4
Net loss before income taxes	(75,178)	(23,418)
Benefit from income taxes	(2,757)
Net loss	$ (72,421)	$ (23,418)
Net loss per share - basic and diluted	$ (0.62)	$ (0.48)
Weighted-average number of common shares - basic and diluted	117,063,352	48,613,565
Comprehensive loss:
Net loss	$ (72,421)	$ (23,418)
Other comprehensive gain (loss) - unrealized gain (loss) on debt securities	225	(108)
Total comprehensive loss	(72,196)	(23,526)
Product Revenue, Net
Revenues:
Total revenues	23,111
License, Collaboration and Other Revenue
Revenues:
Total revenues	$ 49,555	$ 45,930