Accrued Expenses

3 Months Ended

Mar. 31, 2019

Payables And Accruals [Abstract]

Accrued Expenses

10. Accrued Expenses

Accrued expenses as of March 31, 2019 and December 31, 2018 are as follows:

	March 31, 2019		December 31, 2018
	(in thousands)
Accrued clinical expenses	$	76,437	$	71,881
Product revenue allowances		22,606		22,861
Professional fees		4,623		2,367
Lease liability		4,677
Accrued bonus		4,215		9,537
Accrued commercial manufacturing		3,118		6,383
Royalties		2,114		2,430
Accrued vacation		1,058		1,088
Accrued payroll		1,024		2,255
Merger costs		799		16,071
Accrued severance		202		3,962
Accrued other		16,930		12,082
Total accrued expenses	$	137,803	$	150,917