Accrued Expenses (Tables)

12 Months Ended

Dec. 31, 2017

Payables And Accruals [Abstract]

Components of Accrued Expenses

Accrued expenses are as follows:

	December 31, 2017		December 31, 2016
	(in thousands)
Accrued clinical	$	43,297	$	23,643
Accrued bonus		3,388		2,995
Income tax payable		987		—
Professional fees		808		539
Accrued vacation		797		513
Accrued payroll		795		596
Accrued severance		—		29
Other		2,369		1,946
Total accrued expenses	$	52,441	$	30,261