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Net Loss per Share
 12 Months Ended
Dec. 31, 2017
Earnings Per Share [Abstract]  
Net Loss per Share

12. Net Loss per Share

The shares in the table below were excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect:

 

 

 

Year ended December 31,

 

 

 

2017

 

 

2016

 

 

2015

 

Warrants

 

 

509,611

 

 

 

—

 

 

 

—

 

Outstanding stock options

 

 

3,660,014

 

 

 

3,148,006

 

 

 

2,206,635

 

Unvested restricted stock

 

 

—

 

 

 

92,972

 

 

 

216,716

 

Unvested restricted stock units

 

 

728,738

 

 

 

431,688

 

 

 

24,425

 

Total

 

 

4,898,363

 

 

 

3,672,666

 

 

 

2,447,776