Significant Agreements - Additional Information (Details) - USD ($)		1 Months Ended
	Dec. 11, 2015	Jan. 31, 2016	Dec. 31, 2015	Jun. 30, 2016
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue, noncurrent				$ 40,000,000
Development and Commercialize Collaboration Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Maximum percentage of royalty payments	20.00%
Collaboration Agreement, expiration period	10 years
Collaboration Agreement, notice period for termination	12 months
Deferred revenue, noncurrent				$ 40,000,000
Development and Commercialize Collaboration Agreement | Upfront
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone revenue		$ 40,000,000
Milestone revenue refundable		$ 20,000,000
Development and Commercialize Collaboration Agreement | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone revenue			$ 350,000,000
Development and Commercialize Collaboration Agreement | Maximum | Upfront
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone revenue	$ 100,000,000		$ 100,000,000
Development and Commercialize Collaboration Agreement | Maximum | Additional Milestone Payments
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone revenue	$ 250,000,000