XML 38 R26.htm IDEA: XBRL DOCUMENT v3.5.0.2
Nature of Organization and Operations - Additional Information (Details)
1 Months Ended 3 Months Ended 6 Months Ended 18 Months Ended
Dec. 11, 2015
USD ($)
May 31, 2016
USD ($)
Jan. 31, 2016
USD ($)
$ / shares
shares
Dec. 31, 2015
USD ($)
Jun. 30, 2016
USD ($)
shares
Jun. 30, 2016
USD ($)
Patient
Jun. 30, 2016
USD ($)
Underwritten_offering
Nature Of Organization And Operations [Line Items]              
Cash and cash equivalents and available for sale securities       $ 138,454,000 $ 188,649,000 $ 188,649,000 $ 188,649,000
Cash and cash equivalents         188,600,000 188,600,000 188,600,000
Current accounts payable and accrued expenses         $ 20,900,000 $ 20,900,000 20,900,000
Cantor Fitzgerald & Co              
Nature Of Organization And Operations [Line Items]              
Issuance of common stock, shares | shares         0    
IPO              
Nature Of Organization And Operations [Line Items]              
Proceeds from issuance of initial public offering             $ 187,400,000
Number of underwritten public offerings | Underwritten_offering             3
Follow-on public offering              
Nature Of Organization And Operations [Line Items]              
Proceeds from issuance of initial public offering     $ 61,000,000        
Sale of stock, price per share | $ / shares     $ 9.00        
Follow-on public offering | Common Stock              
Nature Of Organization And Operations [Line Items]              
Issuance of common stock, shares | shares     7,250,000        
Minimum              
Nature Of Organization And Operations [Line Items]              
Expected to incur substantial losses (in years)           4 years  
Maximum              
Nature Of Organization And Operations [Line Items]              
Expected to incur substantial losses (in years)           5 years  
Maximum | Cantor Fitzgerald & Co              
Nature Of Organization And Operations [Line Items]              
Common stock sales agreement amount   $ 75,000,000          
Phase 3 vadadustat program | Minimum              
Nature Of Organization And Operations [Line Items]              
Cost of program per patient           $ 80,000  
Phase 3 vadadustat program | Maximum              
Nature Of Organization And Operations [Line Items]              
Cost of program per patient           $ 85,000  
PRO2TECT              
Nature Of Organization And Operations [Line Items]              
Number of patients | Patient           3,100  
INNO2VATE              
Nature Of Organization And Operations [Line Items]              
Number of patients | Patient           2,600  
Development and Commercialize Collaboration Agreement              
Nature Of Organization And Operations [Line Items]              
Collaborative arrangement right description           In December 2015, the Company entered into a collaboration agreement with Mitsubishi Tanabe to develop and commercialize vadadustat in Japan and certain other countries in Asia for total milestone payments of up to $350.0 million, including up to $100.0 million in upfront and development payments, of which $40.0 million was received in January 2016. If Japanese patients are not included in either the global Phase 3 PRO2TECT or INNO2VATE programs, $20.0 million of the $40.0 million received would be used to fund further local development of vadadustat in Japan or be refunded to Mitsubishi. In addition, the Company will receive tiered double-digit royalty payments on sales of vadadustat.  
Development and Commercialize Collaboration Agreement | Upfront              
Nature Of Organization And Operations [Line Items]              
Milestone revenue     $ 40,000,000        
Milestone revenue refundable     $ 20,000,000        
Development and Commercialize Collaboration Agreement | Maximum              
Nature Of Organization And Operations [Line Items]              
Milestone revenue       350,000,000      
Development and Commercialize Collaboration Agreement | Maximum | Upfront              
Nature Of Organization And Operations [Line Items]              
Milestone revenue $ 100,000,000     $ 100,000,000