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Income Taxes - Schedule of Tax Effect of Temporary Differences to Significant Portions of Deferred Tax Assets (Details) - USD ($)
$ in Thousands
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2012
Dec. 31, 2011
Deferred tax assets:        
Loss carryforwards $ 222,902 $ 185,892 $ 200 $ 200
Tax credits 184,961 158,791    
Stock options 39,154 40,676    
Accruals and reserves 24,922 19,622    
Fixed assets and intangibles 7,242 3,870    
Liability related to sale of future royalties 86,664 81,424    
Other 28,642 4,183    
Gross deferred tax assets 594,487 494,458    
Valuation allowance (561,139) (486,796)    
Total deferred tax assets 33,348 7,662    
Deferred tax liabilities:        
Gross deferred tax liabilities (66,654) (40,968)    
Net deferred tax liabilities (33,306) (33,306)    
Right-of-use Lease Assets        
Deferred tax liabilities:        
Gross deferred tax liabilities (10,329) (7,662)    
Basis Difference in Equity Investments        
Deferred tax liabilities:        
Gross deferred tax liabilities (23,019)      
In-process Research and Development        
Deferred tax liabilities:        
Gross deferred tax liabilities $ (33,306) $ (33,306)