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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Revenues:      
Total revenues $ 271,030 $ 103,714 $ 51,495
Operating expenses:      
Cost of sales 6,129 9,008 1,146
Research and development 412,084 357,355 293,998
Selling, general and administrative 182,933 161,524 127,724
Total operating expenses 601,146 527,887 422,868
Loss from operations (330,116) (424,173) (371,373)
Interest income 7,038 13,238 9,542
Gain from sale of priority review vouchers     170,322
Change in fair value of equity investments 170,403 13,413  
Non-cash interest expense on liability related to the sale of future royalties (33,291) (1,135)  
Other income (expense) 607 (787) (5,588)
Loss before income taxes (185,359) (399,444) (197,097)
Provision for income taxes (1,207) (3,283) (514)
Net loss $ (186,566) $ (402,727) $ (197,611)
Net loss per share, basic and diluted $ (3.07) $ (7.12) $ (3.97)
Shares used in computing net loss per share, basic and diluted 60,845,550 56,576,885 49,775,223
Collaboration and License      
Revenues:      
Total revenues $ 219,315 $ 83,493 $ 41,693
Product Sales      
Revenues:      
Total revenues 38,720 $ 20,221 $ 9,802
Non-cash Collaboration Royalty Revenue      
Revenues:      
Total revenues $ 12,995