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Revenue (Tables)
12 Months Ended
Dec. 31, 2020
Revenue From Contract With Customer [Abstract]  
Summary of Disaggregation of Total Revenues

The following table disaggregates total revenues from external customers by collaboration and license revenue and product sales (in thousands):

 

Year Ended December 31,

 

 

2020

 

 

2019

 

 

2018

 

Collaboration and license revenue:

 

 

 

 

 

 

 

 

 

 

 

Crysvita collaboration revenue in profit-share territory

$

128,597

 

 

$

74,869

 

 

$

15,334

 

Crysvita royalty revenue in European territory

 

1,498

 

 

 

8,120

 

 

 

2,892

 

Daiichi Sankyo

 

89,220

 

 

 

 

 

 

 

Bayer

 

 

 

 

504

 

 

 

23,467

 

Total collaboration and license revenue

 

219,315

 

 

 

83,493

 

 

 

41,693

 

Product sales:

 

 

 

 

 

 

 

 

 

 

 

Crysvita

 

10,350

 

 

 

4,286

 

 

 

644

 

Mepsevii

 

15,342

 

 

 

12,634

 

 

 

7,903

 

Dojolvi

 

13,028

 

 

 

3,301

 

 

 

1,255

 

Total product sales

 

38,720

 

 

 

20,221

 

 

 

9,802

 

Crysvita non-cash collaboration royalty revenue

 

12,995

 

 

 

 

 

 

 

Total revenues

$

271,030

 

 

$

103,714

 

 

$

51,495

 

 

The following table disaggregates total revenues based on geographic location (in thousands):

 

Year Ended December 31,

 

 

2020

 

 

2019

 

 

2018

 

North America

$

237,666

 

 

$

86,442

 

 

$

45,339

 

Europe

 

21,318

 

 

 

12,085

 

 

 

5,293

 

All other

 

12,046

 

 

 

5,187

 

 

 

863

 

Total revenues

$

271,030

 

 

$

103,714

 

 

$

51,495

 

Schedule of Sales-Related Accruals and Allowances

The following table presents the activity and ending balances for sales-related accruals and allowances (in thousands):

 

December 31,

 

 

2020

 

 

 

 

2019

 

 

 

 

2018

 

Balance of product sales reserve at beginning of year

$

1,818

 

 

 

 

$

1,240

 

 

 

 

$

41

 

Provisions

 

5,763

 

 

 

 

 

3,846

 

 

 

 

 

2,148

 

Payments

 

(2,785

)

 

 

 

 

(2,739

)

 

 

 

 

(949

)

Adjustments

 

(883

)

 

 

 

 

(529

)

 

 

 

 

 

Balance of product sales reserve at end of year

$

3,913

 

 

 

 

$

1,818

 

 

 

 

$

1,240

 

Summary of Changes in Contract Assets (Liabilities)

The following table presents changes in the contract assets (liabilities) for the years ended December 31, 2020 and 2019 (in thousands):

 

December 31,

 

 

2020

 

 

2019

 

Balance of contract assets at beginning of period

$

 

 

$

2,979

 

Additions

 

(155,788

)

 

 

504

 

Deductions

 

89,220

 

 

 

(3,483

)

Balance of contract liabilities at end of period, net

$

(66,568

)

 

$