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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Operating activities:      
Net loss $ (197,611,000) $ (302,139,000) $ (245,874,000)
Adjustments to reconcile net loss to net cash used in operating activities:      
Stock-based compensation 80,107,000 68,014,000 48,309,000
Amortization of premium (discount) on investment securities, net (2,641,000) 1,706,000 4,842,000
Depreciation and amortization 19,538,000 5,825,000 3,424,000
Foreign currency remeasurement (gain) loss 5,309,000 (7,018,000) 1,322,000
Gain on sale of priority review voucher (170,322,000)    
Other (156,000)   700,000
Changes in operating assets and liabilities:      
Accounts receivable (7,583,000) (5,172,000)  
Inventory (5,283,000) (757,000)  
Prepaid expenses and other current assets (13,908,000) 2,591,000 (7,147,000)
Other assets (377,000) 522,000 (1,242,000)
Accounts payable 3,372,000 3,459,000 2,502,000
Accrued liabilities and other liabilities (1,011,000) (4,628,000) 32,189,000
Deferred tax liabilities   (16,246,000)  
Net cash used in operating activities (290,566,000) (253,843,000) (160,975,000)
Investing activities:      
Acquisition, net of cash acquired   (142,804,000)  
Purchase of property and equipment (4,076,000) (2,793,000) (10,188,000)
Purchase of investments (509,796,000) (230,487,000) (442,490,000)
Proceeds from sale of investments 7,655,000 157,934,000 140,556,000
Proceeds from maturities of investments 302,564,000 273,632,000 403,239,000
Proceeds from sale of priority review vouchers 170,322,000    
Net cash provided by (used in) investing activities (33,331,000) 55,482,000 91,117,000
Financing activities:      
Proceeds from the issuance of common stock in connection with underwritten public offerings, net 270,969,000    
Proceeds from the issuance of common stock in connection with at-the-market offering, net 38,056,000 131,960,000 79,486,000
Proceeds from the issuance of common stock in connection with collaboration agreement, net     51,356,000
Proceeds from the issuance of common stock under equity plan awards, net of tax 27,828,000 9,251,000 7,834,000
Repayment of note payable   (4,944,000)  
Net cash provided by financing activities 336,853,000 136,267,000 138,676,000
Effect of exchange rate changes on cash (472,000) 528,000 (65,000)
Net increase (decrease) in cash, cash equivalents, and restricted cash 12,484,000 (61,566,000) 68,753,000
Cash, cash equivalents, and restricted cash at beginning of year 103,041,000 164,607,000 95,854,000
Cash, cash equivalents, and restricted cash at end of year 115,525,000 103,041,000 164,607,000
Supplemental disclosures of non-cash investing and financing information:      
Stock-based compensation capitalized into inventory 1,058,000 0 0
Fair value of vested stock options assumed in acquisition   8,979,000  
Costs of property and equipment included in accounts payable and accrued liabilities $ 1,192,000 $ 400,000 147,000
Tenant improvement allowance     $ 3,467,000