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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance at Dec. 31, 2014 $ 184,945 $ 32 $ 324,128 $ (174) $ (139,041)
Beginning balance, shares at Dec. 31, 2014   31,934,682      
Issuance of common stock in connection with underwritten public offering, net of issuance costs 461,136 $ 6 461,130    
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares   5,980,000      
Employee stock-based compensation 24,884   24,884    
Issuance of common stock under equity plan awards, net of tax 6,437 $ 1 6,436    
Issuance of common stock under equity plan awards, net of tax, shares   967,712      
Other comprehensive income (loss) (694)     (694)  
Net loss (145,618)       (145,618)
Ending balance at Dec. 31, 2015 531,090 $ 39 816,578 (868) (284,659)
Ending balance, shares at Dec. 31, 2015   38,882,394      
Issuance of common stock in connection with at-the-market offering, net of issuance costs 79,486 $ 1 79,485    
Issuance of common stock in connection with at-the-market offering, net of issuance costs, shares   1,159,415      
Issuance of common stock in connection with collaboration agreement, net of issuance costs 52,272 $ 1 52,271    
Issuance of common stock in connection with collaboration agreement, net of issuance costs, shares   727,120      
Put option grant in connection with collaboration agreement (916)   (916)    
Employee stock-based compensation 48,309   48,309    
Issuance of common stock under equity plan awards, net of tax 7,834   7,834    
Issuance of common stock under equity plan awards, net of tax, shares   471,301      
Other comprehensive income (loss) 1,773     1,773  
Net loss (245,874)       (245,874)
Ending balance at Dec. 31, 2016 $ 473,974 $ 41 1,003,561 905 (530,533)
Ending balance, shares at Dec. 31, 2016 41,240,230 41,240,230      
Issuance of common stock in connection with at-the-market offering, net of issuance costs $ 131,960 $ 2 131,958    
Issuance of common stock in connection with at-the-market offering, net of issuance costs, shares   2,251,217      
Fair value of vested stock options assumed from acquisition 8,979   8,979    
Employee stock-based compensation 68,014   68,014    
Issuance of common stock under equity plan awards, net of tax 9,251 $ 1 9,250    
Issuance of common stock under equity plan awards, net of tax, shares   675,624      
Other comprehensive income (loss) (6,585)     (6,585)  
Net loss (302,139)       (302,139)
Ending balance at Dec. 31, 2017 $ 383,454 $ 44 $ 1,221,762 $ (5,680) $ (832,672)
Ending balance, shares at Dec. 31, 2017 44,167,071 44,167,071