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CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND SHAREHOLDERS' EQUITY (DEFICIT) - USD ($)
$ in Thousands
Total
Series A Redeemable Convertible Preferred Stock
Series B Convertible Preferred Stock
Employee Stock Option
Founders Stock
Common Stock
Additional Paid-in Capital
Additional Paid-in Capital
Employee Stock Option
Additional Paid-in Capital
Founders Stock
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance at Dec. 31, 2012 $ (27,047)         $ 3 $ 8       $ (27,058)
Beginning balance, shares at Dec. 31, 2012           3,458,928          
Beginning balance at Dec. 31, 2012   $ 37,458 $ 73,929                
Beginning balance, shares at Dec. 31, 2012   34,349,894 27,081,680                
Issuance of common stock upon exercise of stock options and warrants $ 171         $ 1 170        
Issuance of common stock upon exercise of stock options and warrants , shares 307,366         307,361          
Employee stock-based compensation       $ 389 $ 268     $ 389 $ 268    
Accretion on convertible preferred stock $ (13,543) $ 13,543         (835)       (12,708)
Unrealized gain (loss) on available-for-sale securities 11                 $ 11  
Net loss (35,070)                   (35,070)
Ending balance at Dec. 31, 2013 (74,821)         $ 4       11 (74,836)
Ending balance, shares at Dec. 31, 2013           3,766,289          
Ending balance at Dec. 31, 2013   $ 51,001 $ 73,929                
Ending balance, shares at Dec. 31, 2013   34,349,894 27,081,680                
Conversion of convertible preferred stock to common stock at initial public offering 129,360 $ (55,431) $ (73,929)     $ 19 129,341        
Conversion of convertible preferred stock to common stock at initial public offering, shares   (34,349,894) (27,081,680)     19,598,486          
Reclassification of preferred stock warrant liability 6,743           6,743        
Issuance of common stock in connection with initial public offering, net of issuance costs and preferred stock dividend 121,711         $ 7 121,704        
Issuance of common stock in connection with initial public offering, net of issuance costs and preferred stock dividend, shares           6,624,423          
Issuance of common stock in connection with underwritten public offering, net of issuance costs 60,239         $ 2 60,237        
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares           1,613,879          
Issuance of common stock upon exercise of stock options and warrants $ 736           736        
Issuance of common stock upon exercise of stock options and warrants , shares 305,090         331,605          
Employee stock-based compensation $ 5,394           5,394        
Accretion on convertible preferred stock (4,430) $ 4,430         (27)       (4,403)
Unrealized gain (loss) on available-for-sale securities (185)                 (185)  
Net loss (59,802)                   (59,802)
Ending balance at Dec. 31, 2014 $ 184,945         $ 32 324,128     (174) (139,041)
Ending balance, shares at Dec. 31, 2014 31,934,682         31,934,682          
Issuance of common stock in connection with underwritten public offering, net of issuance costs $ 461,136         $ 6 461,130        
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares           5,980,000          
Issuance of common stock upon exercise of stock options and warrants $ 7,355         $ 1 7,354        
Issuance of common stock upon exercise of stock options and warrants , shares 795,825         957,587          
Employee stock-based compensation $ 24,884           24,884        
Restricted stock units vested during the period, net (918)           (918)        
Restricted stock units vested during the period, net of shares           10,125          
Unrealized gain (loss) on available-for-sale securities (694)                 (694)  
Net loss (145,618)                   (145,618)
Ending balance at Dec. 31, 2015 $ 531,090         $ 39 $ 816,578     $ (868) $ (284,659)
Ending balance, shares at Dec. 31, 2015 38,882,394         38,882,394