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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2012
Dec. 31, 2011
Tax Credit Carryforward [Line Items]          
Current state income tax expense $ (60) $ 7,336 $ 1,044    
Deferred tax assets net operating loss, federal tax credits       $ 200 $ 200
Deferred tax assets net operating loss carryforwards 266,253 231,835      
Valuation allowance increased 141,300 193,800      
Effective income tax rate unrecognized tax benefits 1,300        
Deferred tax liability increase (decrease), net (1,600)        
Deferred income tax expense 1,608 1,640      
Recognized accrued interest and penalties 200 0 $ 0    
Undistributed earnings of foreign subsidiaries 10,800        
Federal          
Tax Credit Carryforward [Line Items]          
Deferred tax assets operating loss carryforwards subject to expiration $ 1,004,800 756,600      
Operating loss carryforwards expiration year 2031        
Tax credit carryforwards $ 46,900 32,600      
Tax credit carryforwards expiration year 2030        
Deferred tax assets net operating loss carryforwards       3,600 3,600
Federal | Orphan Drug Credits [Member]          
Tax Credit Carryforward [Line Items]          
Deferred tax assets operating loss carryforwards subject to expiration $ 269,600 239,300      
Operating loss carryforwards expiration year 2031        
State          
Tax Credit Carryforward [Line Items]          
Current state income tax expense $ 4,800 6,100      
Deferred tax assets operating loss carryforwards subject to expiration $ 659,900 710,000      
Operating loss carryforwards expiration year 2031        
Tax credit carryforwards $ 74,400 $ 59,900      
Deferred tax assets net operating loss carryforwards       $ 3,600 $ 3,600
International          
Tax Credit Carryforward [Line Items]          
Current state income tax expense $ 3,000