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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Common Stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Beginning balance at Dec. 31, 2019 $ 653,764 $ 58 $ 2,086,863 $ (147) $ (1,433,010)
Beginning balance, shares at Dec. 31, 2019   57,838,220      
Issuance of common stock in connection with underwritten public offering, net of issuance costs 435,556 $ 5 435,551    
Issuance of common stock in connection with underwritten public offering, net of issuance costs, shares   5,111,110      
Issuance of common stock in connection with license agreement, net of issuance costs 55,268 $ 1 55,267    
Issuance of common stock in connection with license agreement, net of issuance costs, shares   1,243,913      
Issuance of common stock in connection with at-the-market offering, net of issuance costs 20,391   20,391    
Issuance of common stock in connection with at-the-market offering, net of issuance costs, shares   283,333      
Stock-based compensation 85,833   85,833    
Issuance of common stock upon exercise of warrants and under equity plan awards, net of tax 89,293 $ 3 89,290    
Issuance of common stock upon exercise of warrants and under equity plan awards, net of tax, shares   2,341,944      
Other comprehensive income (loss) 836     836  
Net loss (186,566)       (186,566)
Ending balance at Dec. 31, 2020 1,154,375 $ 67 2,773,195 689 (1,619,576)
Ending balance, shares at Dec. 31, 2020   66,818,520      
Issuance of common stock in connection with at-the-market offering, net of issuance costs $ 78,943 $ 1 78,942    
Issuance of common stock in connection with at-the-market offering, net of issuance costs, shares 1,050,372 1,050,372      
Stock-based compensation $ 105,260   105,260    
Issuance of common stock under equity plan awards, net of tax 40,101 $ 1 40,100    
Issuance of common stock under equity plan awards, net of tax, shares   1,476,106      
Other comprehensive income (loss) (2,093)     (2,093)  
Net loss (454,025)       (454,025)
Ending balance at Dec. 31, 2021 $ 922,561 $ 69 2,997,497 (1,404) (2,073,601)
Ending balance, shares at Dec. 31, 2021 69,344,998 69,344,998      
Stock-based compensation $ 131,710   131,710    
Issuance of common stock under equity plan awards, net of tax 10,813 $ 1 10,812    
Issuance of common stock under equity plan awards, net of tax, shares   852,299      
Other comprehensive income (loss) (5,169)     (5,169)  
Net loss (707,421)       (707,421)
Ending balance at Dec. 31, 2022 $ 352,494 $ 70 $ 3,140,019 $ (6,573) $ (2,781,022)
Ending balance, shares at Dec. 31, 2022 70,197,297 70,197,297