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Intangible Assets, Net - Additional Information (Details) - USD ($)
1 Months Ended 12 Months Ended
Jun. 30, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Finite Lived Intangible Assets [Line Items]        
Research and development expense related to amortization of assets   $ 497,153,000 $ 412,084,000 $ 357,355,000
Intangible asset impairment charges   0    
IPR&D Assets        
Finite Lived Intangible Assets [Line Items]        
Business combination recognized intangible assets   $ 129,000,000.0 129,000,000.0  
Dimension        
Finite Lived Intangible Assets [Line Items]        
Contractual payments received $ 2,300,000      
Intangible assets, remaining amortization period   7 years    
Research and development expense related to amortization of assets   $ 300,000 $ 200,000 $ 200,000