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Revenue (Tables)
12 Months Ended
Dec. 31, 2021
Revenue from Contract with Customer [Abstract]  
Summary of Disaggregation of Total Revenues

The following table disaggregates total revenues from external customers by collaboration and license revenue and product sales (in thousands):

 

Year Ended December 31,

 

 

2021

 

 

2020

 

 

2019

 

Collaboration and license revenue:

 

 

 

 

 

 

 

 

Crysvita collaboration revenue in profit-share territory

$

171,198

 

 

$

128,597

 

 

$

74,869

 

Crysvita royalty revenue in European territory

 

244

 

 

 

1,498

 

 

 

8,120

 

Daiichi Sankyo

 

84,996

 

 

 

89,220

 

 

 

 

Bayer

 

 

 

 

 

 

 

504

 

Total collaboration and license revenue

 

256,438

 

 

 

219,315

 

 

 

83,493

 

Product sales:

 

 

 

 

 

 

 

 

Crysvita

 

21,422

 

 

 

10,350

 

 

 

4,286

 

Mepsevii

 

16,035

 

 

 

15,342

 

 

 

12,634

 

Dojolvi

 

39,560

 

 

 

13,028

 

 

 

3,301

 

Total product sales

 

77,017

 

 

 

38,720

 

 

 

20,221

 

Crysvita non-cash collaboration royalty revenue

 

17,951

 

 

 

12,995

 

 

 

 

Total revenues

$

351,406

 

 

$

271,030

 

 

$

103,714

 

The following table disaggregates total revenues based on geographic location (in thousands):

 

Year Ended December 31,

 

 

2021

 

 

2020

 

 

2019

 

North America

$

301,110

 

 

$

237,666

 

 

$

86,442

 

Europe

 

26,660

 

 

 

21,318

 

 

 

12,085

 

All other

 

23,636

 

 

 

12,046

 

 

 

5,187

 

Total revenues

$

351,406

 

 

$

271,030

 

 

$

103,714

 

Schedule of Sales-Related Accruals and Allowances

The following table presents the activity and ending balances for sales-related accruals and allowances (in thousands):

 

Year Ended December 31,

 

 

2021

 

 

2020

 

 

2019

 

Balance of product sales reserve at beginning of year

$

3,913

 

 

$

1,818

 

 

$

1,240

 

Provisions

 

9,586

 

 

 

5,763

 

 

 

3,846

 

Payments

 

(6,120

)

 

 

(2,785

)

 

 

(2,739

)

Adjustments

 

(198

)

 

 

(883

)

 

 

(529

)

Balance of product sales reserve at end of year

$

7,181

 

 

$

3,913

 

 

$

1,818

 

Summary of Changes in Contract Assets (Liabilities)

The following table presents changes in the contract assets (liabilities) for the years ended December 31, 2021 and 2020 (in thousands):

 

December 31,

 

 

2021

 

 

2020

 

Balance of contract liabilities at beginning of period

$

(66,568

)

 

$

 

Additions

 

(27,504

)

 

 

(155,788

)

Deductions

 

84,996

 

 

 

89,220

 

Balance of contract liabilities at end of period, net

$

(9,076

)

 

$

(66,568

)