Summary of Disaggregation of Total Revenues |
The following table disaggregates total revenues from external customers by collaboration and license revenue and product sales (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
Year Ended December 31, |
|
|
2021 |
|
|
2020 |
|
|
2019 |
|
Collaboration and license revenue: |
|
|
|
|
|
|
|
|
Crysvita collaboration revenue in profit-share territory |
$ |
171,198 |
|
|
$ |
128,597 |
|
|
$ |
74,869 |
|
Crysvita royalty revenue in European territory |
|
244 |
|
|
|
1,498 |
|
|
|
8,120 |
|
Daiichi Sankyo |
|
84,996 |
|
|
|
89,220 |
|
|
|
— |
|
Bayer |
|
— |
|
|
|
— |
|
|
|
504 |
|
Total collaboration and license revenue |
|
256,438 |
|
|
|
219,315 |
|
|
|
83,493 |
|
Product sales: |
|
|
|
|
|
|
|
|
Crysvita |
|
21,422 |
|
|
|
10,350 |
|
|
|
4,286 |
|
Mepsevii |
|
16,035 |
|
|
|
15,342 |
|
|
|
12,634 |
|
Dojolvi |
|
39,560 |
|
|
|
13,028 |
|
|
|
3,301 |
|
Total product sales |
|
77,017 |
|
|
|
38,720 |
|
|
|
20,221 |
|
Crysvita non-cash collaboration royalty revenue |
|
17,951 |
|
|
|
12,995 |
|
|
|
— |
|
Total revenues |
$ |
351,406 |
|
|
$ |
271,030 |
|
|
$ |
103,714 |
|
The following table disaggregates total revenues based on geographic location (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
Year Ended December 31, |
|
|
2021 |
|
|
2020 |
|
|
2019 |
|
North America |
$ |
301,110 |
|
|
$ |
237,666 |
|
|
$ |
86,442 |
|
Europe |
|
26,660 |
|
|
|
21,318 |
|
|
|
12,085 |
|
All other |
|
23,636 |
|
|
|
12,046 |
|
|
|
5,187 |
|
Total revenues |
$ |
351,406 |
|
|
$ |
271,030 |
|
|
$ |
103,714 |
|
|
Schedule of Sales-Related Accruals and Allowances |
The following table presents the activity and ending balances for sales-related accruals and allowances (in thousands):
|
|
|
|
|
|
|
|
|
|
|
|
|
Year Ended December 31, |
|
|
2021 |
|
|
2020 |
|
|
2019 |
|
Balance of product sales reserve at beginning of year |
$ |
3,913 |
|
|
$ |
1,818 |
|
|
$ |
1,240 |
|
Provisions |
|
9,586 |
|
|
|
5,763 |
|
|
|
3,846 |
|
Payments |
|
(6,120 |
) |
|
|
(2,785 |
) |
|
|
(2,739 |
) |
Adjustments |
|
(198 |
) |
|
|
(883 |
) |
|
|
(529 |
) |
Balance of product sales reserve at end of year |
$ |
7,181 |
|
|
$ |
3,913 |
|
|
$ |
1,818 |
|
|
Summary of Changes in Contract Assets (Liabilities) |
The following table presents changes in the contract assets (liabilities) for the years ended December 31, 2021 and 2020 (in thousands):
|
|
|
|
|
|
|
|
|
December 31, |
|
|
2021 |
|
|
2020 |
|
Balance of contract liabilities at beginning of period |
$ |
(66,568 |
) |
|
$ |
— |
|
Additions |
|
(27,504 |
) |
|
|
(155,788 |
) |
Deductions |
|
84,996 |
|
|
|
89,220 |
|
Balance of contract liabilities at end of period, net |
$ |
(9,076 |
) |
|
$ |
(66,568 |
) |
|