The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   4,113,209 430,252 SH   DFND   430,252 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   13,322,227 17,079,778 SH   DFND   17,079,778 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107   408,293 180,000 SH   DFND   180,000 0 0
AFFIMED NV COM N01045108   2,115,419 4,426,488 SH   DFND   4,426,488 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G207   89,303 22,608 SH   DFND   22,608 0 0
ALLAKOS INC COM 01671P100   13,954,280 6,147,260 SH   DFND   6,147,260 0 0
ARCELLX INC COMMON STOCK 03940C100   134,380,001 3,745,262 SH   DFND   3,745,262 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   30,845,610 3,969,834 SH   DFND   3,969,834 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105   12,767,933 4,448,757 SH   DFND   4,448,757 0 0
BRIGHT HEALTH GROUP INC COM NEW 10920V404   16,279,694 2,726,917 SH   DFND   2,726,917 0 0
BUZZFEED INC CLASS A COM 12430A102   5,859,080 15,333,892 SH   DFND   15,333,892 0 0
CELCUITY INC COM 15102K100   31,791,305 1,250,001 SH   DFND   1,250,001 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307   10,642,201 1,713,720 SH   DFND   1,713,720 0 0
COURSERA INC COM 22266M104   240,498,602 12,867,769 SH   DFND   12,867,769 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   72,072,693 1,587,854 SH   DFND   1,587,854 0 0
CVRX INC COM 126638105   35,961,122 2,370,542 SH   DFND   2,370,542 0 0
DESKTOP METAL INC COM CL A 25058X105   21,022,433 14,407,594 SH   DFND   14,407,594 0 0
EARGO INC COM NEW 270087208   188,760 86,946 SH   DFND   86,946 0 0
GERON CORP COM 374163103   48,285,987 22,776,409 SH   DFND   22,776,409 0 0
GLYCOMIMETICS INC COM 38000Q102   7,146,660 4,764,440 SH   DFND   4,764,440 0 0
GOSSAMER BIO INC COM 38341P102   13,098,230 15,727,942 SH   DFND   15,727,942 0 0
IKENA ONCOLOGY INC COM 45175G108   707,200 181,473 SH   DFND   181,473 0 0
INOZYME PHARMA INC COM 45790W108   10,238,294 2,437,689 SH   DFND   2,437,689 0 0
INVENTIVA SA ADS 46124U107   6,346,161 1,462,586 SH   DFND   1,462,586 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   2,596,692 2,382,286 SH   DFND   2,382,286 0 0
MARKER THERAPEUTICS INC COM NEW 57055L206   4,864,283 1,071,428 SH   DFND   1,071,428 0 0
MINERVA SURGICAL INC COM 60343F106   5,664,895 34,437,052 SH   DFND   34,437,052 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   69,085,279 2,186,243 SH   DFND   2,186,243 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   36,846,107 7,692,298 SH   DFND   7,692,298 0 0
NEXTNAV INC COMMON STOCK 65345N106   42,092,262 8,189,156 SH   DFND   8,189,156 0 0
NKARTA INC COM 65487U108   4,960,606 3,568,781 SH   DFND   3,568,781 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   12,238,290 1,276,595 SH   DFND   1,276,595 0 0
REGULUS THERAPEUTICS INC COM 75915K200   2,665,443 1,945,579 SH   DFND   1,945,579 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   36,441,537 4,785,494 SH   DFND   4,785,494 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   66,710,741 2,909,956 SH   DFND   2,909,956 0 0
SAGIMET BIOSCIENCES INC COM SER A 786700104   27,105,936 3,850,275 SH   DFND   3,850,275 0 0
SAVARA INC COM 805111101   92,501,378 24,471,264 SH   DFND   24,471,264 0 0
SENTI BIOSCIENCES INC COM 81726A100   1,828,000 4,426,151 SH   DFND   4,426,151 0 0
SURF AIR MOBILITY INC COM 868927104   610,199 440,418 SH   DFND   440,418 0 0
SYNLOGIC INC COM NEW 87166L209   614,605 281,929 SH   DFND   281,929 0 0
TREVI THERAPEUTICS INC COM 89532M101   24,787,420 11,370,376 SH   DFND   11,370,376 0 0
TUYA INC SPONSERED ADS 90114C107   7,648,692 4,934,640 SH   DFND   4,934,640 0 0
VERONA PHARMA PLC SPONSERED ADS 925050106   91,031,474 5,108,563 SH   DFND   5,108,563 0 0
WHEELS UP EXPERIENCE INC COM CL A 96328L205   219,679 106,126 SH   DFND   106,126 0 0
X4 PHARMACEUTICALS INC COM 98420X103   16,335,604 14,986,793 SH   DFND   14,986,793 0 0
ZEROFOX HLDGS INC COM 98955G103   15,885,837 18,068,513 SH   DFND   18,068,513 0 0