The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 18,364 | 17,082,612 | SH | DFND | 17,082,612 | 0 | 0 | ||
| ADDEX THERAPEUTICS LTD | SPONSORED ADS | 00654J107 | 830 | 5,648,690 | SH | DFND | 5,648,690 | 0 | 0 | ||
| AFFIMED NV | COM | N01045108 | 9,119 | 4,426,488 | SH | DFND | 4,426,488 | 0 | 0 | ||
| AIRSPAN NETWORKS HOLDINGS INC | COM | 00951K104 | 3,100 | 1,534,633 | SH | DFND | 1,534,633 | 0 | 0 | ||
| AKARI THERAPEUTICS PLC | SPONSORED ADR | 00972G108 | 285 | 452,167 | SH | DFND | 452,167 | 0 | 0 | ||
| AKOUOS INC | COM | 00973J101 | 29,058 | 4,298,488 | SH | DFND | 4,298,488 | 0 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 33,867 | 6,148,704 | SH | DFND | 6,148,704 | 0 | 0 | ||
| ARCELLX INC | COM | 03940C100 | 126,702 | 6,750,264 | SH | DFND | 6,750,264 | 0 | 0 | ||
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 29,853 | 3,969,834 | SH | DFND | 3,969,834 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588307 | 32,533 | 3,952,957 | SH | DFND | 3,952,957 | 0 | 0 | ||
| BERKSHIRE GREY INC | COM CL A | 084656107 | 64,985 | 38,226,621 | SH | DFND | 38,226,621 | 0 | 0 | ||
| BILL COM HLDGS INC | COM | 090043100 | 8,312 | 66,100 | SH | DFND | 66,100 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS INC | COM | 09203E105 | 5,830 | 3,449,845 | SH | DFND | 3,449,845 | 0 | 0 | ||
| BRIGHT HEALTH GROUP INC | COM | 10920V107 | 229,123 | 218,212,126 | SH | DFND | 218,212,126 | 0 | 0 | ||
| BUZZFEED INC | CL A COM | 12430A102 | 23,921 | 15,333,892 | SH | DFND | 15,333,892 | 0 | 0 | ||
| CHAMPIONS ONCOLOGY INC | COM NEW | 15870P307 | 12,853 | 1,713,720 | SH | DFND | 1,713,720 | 0 | 0 | ||
| CLOUDFLARE INC | CL A COM | 18915M107 | 103,845 | 1,877,510 | SH | DFND | 1,877,510 | 0 | 0 | ||
| COURSERA INC | COM | 22266M104 | 171,055 | 15,867,769 | SH | DFND | 15,867,769 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 103,907 | 1,590,002 | SH | DFND | 1,590,002 | 0 | 0 | ||
| CTI BIOPHARMA CORP | COM | 12648L601 | 21,451 | 3,685,683 | SH | DFND | 3,685,683 | 0 | 0 | ||
| CVRX INC | COM | 126638105 | 22,120 | 2,370,858 | SH | DFND | 2,370,858 | 0 | 0 | ||
| DESKTOP METAL INC | COM CL A | 25058X105 | 37,316 | 14,407,594 | SH | DFND | 14,407,594 | 0 | 0 | ||
| EARGO INC | COM | 270087109 | 4,747 | 4,520,849 | SH | DFND | 4,520,849 | 0 | 0 | ||
| FISCALNOTE HOLDINGS INC | COM CL A | 337655104 | 8,634 | 1,694,323 | SH | DFND | 1,694,323 | 0 | 0 | ||
| GERON CORP | COM | 374163103 | 38,186 | 16,318,681 | SH | DFND | 16,318,681 | 0 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 5,014 | 9,089,041 | SH | DFND | 9,089,041 | 0 | 0 | ||
| GOSSAMER BIO INC | COM | 38341P102 | 41,540 | 3,467,406 | SH | DFND | 3,467,406 | 0 | 0 | ||
| INOZYME PHARMA INC | COM | 45790W108 | 6,551 | 2,444,379 | SH | DFND | 2,444,379 | 0 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 19,907 | 5,572,953 | SH | DFND | 5,572,953 | 0 | 0 | ||
| IONQ INC | COM | 46222L108 | 133,595 | 26,350,067 | SH | DFND | 26,350,067 | 0 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 5,717 | 2,382,286 | SH | DFND | 2,382,286 | 0 | 0 | ||
| MARKER THERAPEUTICS INC | COM | 57055L107 | 3,951 | 10,714,285 | SH | DFND | 10,714,285 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 3,299 | 8,533,072 | SH | DFND | 8,533,072 | 0 | 0 | ||
| MINERVA SURGICAL INC | COM | 60343F106 | 7,956 | 10,001,937 | SH | DFND | 10,001,937 | 0 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 87,986 | 4,187,801 | SH | DFND | 4,187,801 | 0 | 0 | ||
| MONTE ROSA THERAPEUTICS INC | COM | 61225M102 | 62,935 | 7,703,205 | SH | DFND | 7,703,205 | 0 | 0 | ||
| NEXTNAV INC | COM | 65345N106 | 22,029 | 8,189,156 | SH | DFND | 8,189,156 | 0 | 0 | ||
| NKARTA INC | COM | 65487U108 | 47,003 | 3,571,640 | SH | DFND | 3,571,640 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 652 | 4,586,563 | SH | DFND | 4,586,563 | 0 | 0 | ||
| OYSTER PT PHARMA INC | COM | 69242L106 | 33,300 | 5,925,287 | SH | DFND | 5,925,287 | 0 | 0 | ||
| PALO ALTO NETWORKS INC | COM | 697435105 | 22 | 141 | SH | DFND | 141 | 0 | 0 | ||
| PHASEBIO PHARMACEUTICALS INC | COM | 717224109 | 1,169 | 6,643,702 | SH | DFND | 6,643,702 | 0 | 0 | ||
| REGULUS THERAPEUTICS INC | COM | 75915K200 | 2,457 | 1,445,115 | SH | DFND | 1,445,115 | 0 | 0 | ||
| RENEO PHARMACEUTICALS INC | COM | 75974E103 | 16,036 | 4,786,921 | SH | DFND | 4,786,921 | 0 | 0 | ||
| RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 108,316 | 4,912,306 | SH | DFND | 4,912,306 | 0 | 0 | ||
| SATSUMA PHARMACEUTICALS INC | COM | 80405P107 | 18,858 | 3,142,958 | SH | DFND | 3,142,958 | 0 | 0 | ||
| SAVARA INC | COM | 805111101 | 37,414 | 24,137,931 | SH | DFND | 24,137,931 | 0 | 0 | ||
| SENTI BIOSCIENCES INC | COM | 81726A100 | 8,233 | 4,429,725 | SH | DFND | 4,429,725 | 0 | 0 | ||
| SYNLOGIC INC | COM | 87166L100 | 4,018 | 4,229,410 | SH | DFND | 4,229,410 | 0 | 0 | ||
| TRACON PHARMACEUTICALS INC | COM | 89237H209 | 579 | 346,719 | SH | DFND | 346,719 | 0 | 0 | ||
| TREVI THERAPEUTICS INC | COM | 89532M101 | 17,515 | 11,373,174 | SH | DFND | 11,373,174 | 0 | 0 | ||
| TUYA INC | SPONSERED ADS | 90114C107 | 4,588 | 4,934,640 | SH | DFND | 4,934,640 | 0 | 0 | ||
| VERONA PHARMA PLC | ADS | 925050106 | 57,076 | 5,584,753 | SH | DFND | 5,584,753 | 0 | 0 | ||
| WHEELS UP EXPERIENCE INC | COM CL A | 96328L106 | 1,220 | 1,061,259 | SH | DFND | 1,061,259 | 0 | 0 | ||
| X4 PHARMACEUTICALS INC | COM | 98420X103 | 11,155 | 6,523,157 | SH | DFND | 6,523,157 | 0 | 0 | ||
| XERIS BIOPHARMA HOLDINGS INC | COM | 98422E103 | 5,065 | 3,246,785 | SH | DFND | 3,246,785 | 0 | 0 | ||
| ZEROFOX HLDGS INC | COM | 98955G103 | 88,283 | 18,090,861 | SH | DFND | 18,090,861 | 0 | 0 | ||