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Revenue - Additional Information (Details) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Concentration of Revenue [Line Items]        
Net product revenue $ 82,503 $ 113,551 $ 253,180 $ 365,405
Net Product Revenue.        
Concentration of Revenue [Line Items]        
Net product revenue $ 82,500 $ 113,600 $ 253,200 $ 365,400