Filed pursuant to Rule 497(j)
Registration Nos. 333-171759 and 811-22519 

Chapman and Cutler LLP 320 South Canal Street, 27th Floor Chicago, Illinois 60606   T 312.845.3000 F 312.701.2361 www.chapman.com

May 1, 2023

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Re: First Trust Exchange-Traded AlphaDEX Fund II
(Registration Nos. 333-171759 and 811-22519)

Ladies and Gentlemen:

On behalf of First Trust Exchange-Traded AlphaDEX Fund II (the “Registrant”), in accordance with the provisions of Rule 497(j) of Regulation C under the Securities Act of 1933, as amended, (the “Securities Act”), this letter serves to certify that the most recent amendment to the Registration Statement on Form N-1A (the “Registration Statement”) of the Registrant does not differ from that which would have been filed pursuant to Rule 497(c) of the Securities Act. The Registration Statement relates to First Trust Asia Pacific ex-Japan AlphaDEX^® Fund, First Trust Brazil AlphaDEX^® Fund, First Trust China AlphaDEX^® Fund, First Trust Developed Markets ex-US AlphaDEX^® Fund, First Trust Developed Markets ex-US Small Cap AlphaDEX^® Fund, First Trust Emerging Markets AlphaDEX^® Fund, First Trust Emerging Markets Small Cap AlphaDEX^® Fund, First Trust Europe AlphaDEX^® Fund, First Trust Eurozone AlphaDEX^® ETF, First Trust Germany AlphaDEX^® Fund, First Trust India NIFTY 50 EqualWeight ETF, First Trust Japan AlphaDEX^® Fund, First Trust Latin America AlphaDEX^® Fund, First Trust Switzerland AlphaDEX^® Fund and First Trust United Kingdom AlphaDEX^® Fund, each a series of the Registrant. Post-Effective Amendment No. 93 to the Registration Statement was filed electronically with the Securities and Exchange Commission on April 28, 2023.

If you have any questions or comments, please telephone the undersigned at (312) 845-3484.

Very truly yours,
Chapman and Cutler llp
By:	/s/ Morrison C. Warren
	Morrison C. Warren

Enclosures