Total

Outstanding

and

Exercisable

Underlying

Shares of

Common

Stock

Exercise

Price per

Share

Expiration Date

Series 1 Warrants issued in the February 2018 Series B financing

8,979,000

44,895

$

400.00

February 2025

Series 2 Warrants issued in the February 2018 Series B financing

8,709,500

43,548

$

400.00

February 2025

Warrants issued in the November 2018 financing

8,768,395

43,842

$

80.00

November 2023

Placement agent warrants issued in the January 2022 financing

1,330,000

66,500

$

10.00

January 2027

Warrants issued in the January 2022 financing

16,150,000

807,500

$

9.60

July 2027

Pre-funded warrants issued in the August 2022 financing

1,369,864

$

0.0001

n/a

Series A Preferred Investment Options issued in August 2022 financing

2,853,883

$

1.502

February 2028

Series B Preferred Investment Options issued in August 2022 financing

2,853,883

$

1.502

August 2024

Placement agent Preferred Investment Options issued in the August 2022 financing

171,233

$

2.19

August 2027

Total as of December 31, 2022

51,185,758

8,255,148