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Changes in Amount of Unrecognized Tax Benefits (Detail) (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Income Tax Contingency [Line Items]      
Beginning balance of unrecognized tax benefits $ 1,092us-gaap_UnrecognizedTaxBenefits $ 569us-gaap_UnrecognizedTaxBenefits $ 406us-gaap_UnrecognizedTaxBenefits
Increase (decrease) for prior year tax positions (73)rgls_UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromPriorPeriodTaxPositions 137rgls_UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromPriorPeriodTaxPositions 50rgls_UnrecognizedTaxBenefitsIncreasesDecreasesResultingFromPriorPeriodTaxPositions
Increase for current year tax positions 834us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions 386us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions 113us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
Total $ 1,853us-gaap_UnrecognizedTaxBenefits $ 1,092us-gaap_UnrecognizedTaxBenefits $ 569us-gaap_UnrecognizedTaxBenefits