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Selected Quarterly Financial Information (Unaudited) - Schedule of Selected Quarterly Financial Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]                      
License and other revenue $ 1,534 $ 0 $ 3 $ 68 $ 47 $ 48 $ 59   $ 1,605 $ 154 $ 250
Total operating expenses 40,986 31,055 29,755 30,347 27,212 25,790 30,535 $ 27,349 132,143 110,886 119,326
Loss from operations (39,452) (31,055) (29,752) (30,279) (27,165) (25,742) (30,476) (27,349) (130,538) (110,732) (119,076)
Total other income (expense) 421 428 383 385 369 317 318 290 (81) 10 (2)
Net loss $ (39,040) $ (30,640) $ (29,387) $ (29,917) $ (26,935) $ (25,425) $ (30,158) $ (27,059) $ (128,984) $ (109,577) $ (118,181)
Net loss per share, basic and diluted $ (0.80) $ (0.65) $ (0.64) $ (0.71) $ (0.65) $ (0.69) $ (0.84) $ (0.75) $ (2.81) $ (2.92) $ (3.32)