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Net Loss Per Share - Schedule of Potentially Dilutive Securities Were Excluded From The Calculation of Diluted Net Loss Per Share Due to Their Anti-Dilutive Effect (Detail) - shares
3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Outstanding Stock Options [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Dilutive securities excluded from the calculation of diluted net loss per share due to anti-dilutive effect (in shares) 6,867,142 5,371,000
Unvested Restricted Stock Units [Member]    
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]    
Dilutive securities excluded from the calculation of diluted net loss per share due to anti-dilutive effect (in shares) 462,250 495,400