Long-Term Obligations - Additional Information (Detail)				1 Months Ended	12 Months Ended
	Oct. 15, 2022 Days	Jan. 01, 2021 USD ($)	Oct. 16, 2018 USD ($)	Sep. 30, 2019 USD ($)	Dec. 31, 2023 USD ($) Days $ / shares shares	Dec. 31, 2022 USD ($)	Aug. 01, 2023 $ / shares shares	Oct. 26, 2018 USD ($)
Subsequent Event [Line Items]
Accumulated deficit					$ (1,487,038,000)	$ (1,343,939,000)
Debt instrument convertible threshold consecutive trading days | Days					5
Description of debt instrument convertible period					during the five-business day period immediately after any five consecutive trading day period
Principal amount of notes used in conversion rate					$ 1,000
Debt instrument convertible threshold maximum percentage of product of last reported sale price of common stock					98.00%
Fair Value of embeded derivative liability					$ 2,800,000	2,800,000
Deferred Royalty Obligation [Member]
Subsequent Event [Line Items]
Purchase of shares of common stock | shares							250,000
Exercise price | $ / shares							$ 2.25
Deferred Royalty Obligation [Member] | Level 3 [Member]
Subsequent Event [Line Items]
Deferred royalty obligation at fair value					129,700,000	129,900,000
Revenue Interest Financing Agreement [Member]
Subsequent Event [Line Items]
Debt issuance costs					$ 1,400,000
First investment amount				$ 75,000,000
Revenue Interest Financing Agreement [Member] | HealthCare Royalty Partners IV LP [Member] | Royalty Due On December 31, 2024 [Member]
Subsequent Event [Line Items]
Royalty Payable Percentage on First Investment Amount					100.00%
Amended Revenue Interest Agreement [Member]
Subsequent Event [Line Items]
Second investment amount					$ 60,000,000
Amended Revenue Interest Agreement [Member] | HealthCare Royalty Partners IV LP [Member] | Royalty Due On December 31, 2024 [Member]
Subsequent Event [Line Items]
Royalty Payable Percentage on Second Investment Amount					65.00%
Amended Revenue Interest Agreement [Member] | HealthCare Royalty Partners IV LP [Member] | Royalty Due On September 30, 2026 [Member]
Subsequent Event [Line Items]
Royalty Payable Percentage on First Investment Amount					100.00%
Royalty Payable Percentage on Second Investment Amount					100.00%
Revenue Interest Agreement And Amended Revenue Interest Agreement [Member]
Subsequent Event [Line Items]
First investment amount					$ 135,000,000	135,000,000
Debt Instrument Interest Rate					15.00%
Revenue Interest Agreement And Amended Revenue Interest Agreement [Member] | HealthCare Royalty Partners IV LP [Member]
Subsequent Event [Line Items]
Aggregate Royalties Percentage					195.00%		185.00%
Cumulative payments					$ 61,700,000
Minimum [Member] | Deferred Royalty Obligation [Member]
Subsequent Event [Line Items]
Aggregate Royalties Percentage							185.00%
Maximum [Member] | Deferred Royalty Obligation [Member]
Subsequent Event [Line Items]
Aggregate Royalties Percentage							195.00%
Convertible Note Offering [Member]
Subsequent Event [Line Items]
Notes converted in to common stock, amount | shares					63.0731
Notes converted in to common stock, shares					$ 1,000
Notes, conversion price per share | $ / shares					$ 15.85
3% Convertible Senior Notes Due 2025 [Member]
Subsequent Event [Line Items]
Principal			$ 150,000,000		$ 172,500,000	172,500,000		$ 22,500,000
Debt issuance costs					5,600,000
Debt issuance costs allocated to equity component and recorded as a reduction to additional paid-in capital					2,200,000
Debt issuance costs allocated to liability component and recorded as a reduction of convertible notes					$ 3,400,000
Debt discount and issuance costs amortized to interest expense, amortization period					7 years
Notes, interest rate			3.00%		3.00%
Notes, maturity date					Oct. 15, 2025
Principal amount of notes used in conversion rate					$ 1,000
Debt instrument, convertible latest date					Jun. 15, 2025
Notes conversion price, percentage	130.00%				130.00%
Notes instrument, trading days | Days	20				20
Debt instrument convertible threshold consecutive trading days | Days	30				30
Notes, repurchase price	100.00%
Estimated fair value of convertible notes					$ 87,900,000	$ 133,100,000
Expected life of convertible notes					7 years
Debt Instrument Interest Rate					3.53%
3% Convertible Senior Notes Due 2025 [Member] | ASU 2020-06 [Member]
Subsequent Event [Line Items]
Decrease to additional paid-in capital		$ (65,600,000)
Accumulated deficit		(15,000,000)
Decrease in deferred tax liability		(11,800,000)
3% Convertible Senior Notes Due 2025 [Member] | Convertible Note Offering [Member] | ASU 2020-06 [Member]
Subsequent Event [Line Items]
Increase in carrying value of debt		$ 50,600,000