Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
U.S. and state net operating loss carryforwards	$ 187,762	$ 179,462
Research and development credits	88,091	75,189
Fixed assets and intangible assets	28,268	9,602
Stock-based compensation	12,555	13,814
Accruals and other temporary differences	5,964	4,970
Interest Expense - Sec 163(j)	3,704	1,321
Lease liability	2,676	3,084
AHYDO Interest	2,069	1,017
Capitalized research and development	388	708
Deferred royalty embedded derivative	720	421
Unicap - Sec 263A	903	190
Transaction Costs		92
Valuation allowance	(330,902)	(275,389)
Total deferred tax assets	2,198	14,481
Deferred tax liabilities:
Convertible debt amortization	6	(11,825)
Right-of-use asset	1,849	(2,188)
Deferred royalty obligation	343	(468)
Total deferred tax liabilities	(2,198)	(14,481)
Net deferred tax assets	$ 0	$ 0