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License and Asset Purchase Agreements - Additional Information - Antengene License Agreement (Detail) - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Jun. 30, 2020
May 31, 2020
May 23, 2018
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Deferred Revenue, non-current         $ 1.3  
Amended Antengene Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Upfront payments   $ 13.7 $ 9.4      
Performance obligations         13.0  
Revenues $ 0.3          
Other Assets Recognized Under Development/Regulatory Milestone Revenue 19.5          
Regulatory Milestones received $ 29.3 9.8        
Amended Antengene Agreement [Member] | Government Research Grant Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
License agreement termination prior notice period 180 days          
License agreement termination description Agreement may be terminated earlier by (i) either party for breach of the Amended Antengene Agreement by the other party or in the event of the insolvency or bankruptcy of the other party, (ii) Antengene on a product-by-product basis for certain safety reasons or on a product-by-product, country-by-country basis for any reason with 180 days’ prior notice or (iii) us in the event Antengene challenges or assists with a challenge to certain of our patent rights.          
Amended Antengene Agreement [Member] | Selinexor [Member] | Government Research Grant Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Performance obligations $ 9.4          
Amended Antengene Agreement [Member] | Eltanexor [Member] | Government Research Grant Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Performance obligations 1.1          
Amended Antengene Agreement [Member] | KPT-9274 [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Revenues   1.0 $ 9.4      
Amended Antengene Agreement [Member] | KPT-9274 [Member] | Government Research Grant Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Performance obligations 1.0          
Amended Antengene Agreement [Member] | Verdinexor [Member] | Government Research Grant Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Performance obligations $ 0.2          
Amended Antengene Agreement [Member] | Selinexor and KPT-9274 [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Cumulative adjustment to license revenue   $ 12.7        
Up-front Payment Arrangement [Member] | Amended Antengene Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Performance obligations         11.7  
Up-front Payment Arrangement [Member] | Amended Antengene Agreement [Member] | Government Research Grant Agreement [Member]            
Research and Development Arrangement, Contract to Perform for Others [Line Items]            
Upfront payments       $ 11.7   $ 11.7
Performance obligations         $ 11.7