Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues:
Total revenues	$ 209,819	$ 108,085	$ 40,893
Operating expenses:
Cost of sales	3,402	2,705	2,407
Research and development	160,842	150,813	122,340
Selling, general and administrative	143,846	126,417	105,421
Total operating expenses	308,090	279,935	230,168
Loss from operations	(98,271)	(171,850)	(189,275)
Other income (expense):
Interest income	582	2,820	5,422
Interest expense	(26,046)	(27,140)	(15,647)
Other (expense) income, net	(85)	206	(50)
Total other expense, net	(25,549)	(24,114)	(10,275)
Loss before income taxes	(123,820)	(195,964)	(199,550)
Income tax provision	(268)	(309)	(40)
Net loss	$ (124,088)	$ (196,273)	$ (199,590)
Net loss per share—basic and diluted	$ (1.65)	$ (2.72)	$ (3.22)
Weighted-average number of common shares outstanding used to compute net loss per share—basic and diluted	75,218	72,044	61,955
Product revenue
Revenues:
Total revenues	$ 98,436	$ 76,210	$ 30,540
License and other revenue
Revenues:
Total revenues	$ 111,383	$ 31,875	$ 10,353