Collaboration and License Agreements - ModernaTX, Inc - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended
	Jan. 31, 2023	Mar. 31, 2023	Dec. 31, 2022	Mar. 31, 2022	Dec. 31, 2021
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Deferred revenue		$ 283,917	$ 301,326	$ 276,734	$ 284,760
ModernaTX, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Deferred revenue		34,300
ModernaTX, Inc | Collaboration and License Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Upfront payment received	$ 35,000
Up front consideration pre paid research and development service fees	5,000
Deferred revenue		$ 34,300	$ 35,000
ModernaTX, Inc | Collaboration and License Agreement | Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contingent milestone payments receivable	$ 1,200,000