Commitments and Contingencies - Additional Information (Details) € in Thousands			1 Months Ended											12 Months Ended
	May 16, 2022 USD ($)	Mar. 31, 2021 ft²	Sep. 30, 2022 USD ($)	Aug. 31, 2022 USD ($) OperatingLease	Jan. 31, 2022 USD ($)	Oct. 31, 2020 USD ($)	Jul. 31, 2019 USD ($)	Dec. 31, 2014 USD ($) LicensedProduct	Jan. 31, 2014 USD ($)	Sep. 30, 2013 USD ($)	Jul. 31, 2011 USD ($)	Dec. 31, 2010 USD ($)	Nov. 30, 2009 EUR (€)	Dec. 31, 2022 USD ($) OperatingLease	Dec. 31, 2021 USD ($)
Lessee Lease Description [Line Items]
Operating lease termination date		Jul. 31, 2023
Area of space leased | ft²		4,516
Lease commencement date		May 01, 2021
Additional square feet of laboratory space | ft²		1,000
Additional leased space commencement date		Jun. 15, 2021
Lease existence of option to extend		true
Operating lease, option to extend term		12 months
Recognized loss on lease														$ 296,000
Operating lease liabilities														20,858,000
Estimated payments due														33,949,000
Expenses related to license agreement														42,238,000	$ 25,161,000
Biologic Materials License Agreement
Lessee Lease Description [Line Items]
One time non refundable license issuance fee												$ 20,000.00
Milestone payments or royalties												$ 0
National Institute of Health
Lessee Lease Description [Line Items]
License issue royalty fee										$ 100,000
Sales milestone payments										600,000
Development and regulatory milestone payments										$ 700,000
Expenses for Patent Licensing Fees														20,000.00	30,000.00
Patent licensing reimbursement fees														30,000.00
Royalty Bearing Patent License Agreement
Lessee Lease Description [Line Items]
Expenses														0	0
License agreement term													10 years
Royalty Bearing Patent License Agreement | IND Filing
Lessee Lease Description [Line Items]
Potential milestone payments | €													€ 10
Clearside
Lessee Lease Description [Line Items]
Expenses														0	0
Upfront payment							$ 100,000
License agreement expiration period							10 years
Royalties on net sales							20.00%
Clearside | Maximum
Lessee Lease Description [Line Items]
Aggregate milestones payment							$ 21,000,000.0
Termination Agreement
Lessee Lease Description [Line Items]
Landlord termination expense				$ 300,000
Recognized loss on lease														(300,000)
Operating lease liabilities														600,000
LI-COR, Inc. | Exclusive License and Supply Agreement
Lessee Lease Description [Line Items]
One-time upfront license issuance fee									$ 100,000
Expenses related to license agreement														0	0
License agreement term									10 years
LI-COR, Inc. | Exclusive License and Supply Agreement | Maximum
Lessee Lease Description [Line Items]
Aggregate milestone payments									$ 200,000
LI-COR, Inc. | 2014 Non- Exclusive Agreement
Lessee Lease Description [Line Items]
License issue fee								$ 30,000.00
Expenses related to license agreement														100,000
Milestone Payments														0	0
LI-COR, Inc. | 2014 Non- Exclusive Agreement | Maximum
Lessee Lease Description [Line Items]
License issue fee								300,000
Payments for development and commercial milestones								400,000
Life Technologies
Lessee Lease Description [Line Items]
Non-refundable, Non- creditable fee								$ 300,000
Number of licensed products | LicensedProduct								5
Initial license fee								$ 100,000
Annual development fee								100,000
Change of control fees			$ 500,000					$ 200,000
Expenses														50,000.00	100,000
One time perpetual license agreement fee					$ 50,000.00
Initial license fee for first licensed product			400,000
Initial license fee for additional licensed product			500,000
Payment for sublicense			200,000
Payment for use of cell line document package			30,000.00
Expense related to agreement including sublicense														400,000
Dr. John Schiller | 2014 Non- Exclusive Agreement
Lessee Lease Description [Line Items]
Required amendment payment			$ 40,000.00
Required amendment payment due period			30 days
Dr. John Schiller | Collaboration Research and Development Agreement
Lessee Lease Description [Line Items]
Annual development fee											$ 30,000.00
Agreement term											2 years
First payment due											30 days
Subsequent payments due											30 days
Research collaboration fees														$ 0	$ 30,000.00
Required amendment payment						$ 40,000.00
Required amendment payment due period						30 days
Dr. John Schiller | Collaboration Research and Development Agreement | 10th Anniversary
Lessee Lease Description [Line Items]
Required amendment payment			$ 30,000.00			$ 30,000.00
Required amendment payment due period			30 days			30 days
Office and Laboratory Facility
Lessee Lease Description [Line Items]
Number of operating lease | OperatingLease														1
Number of Operating Lease Terminated | OperatingLease				1
Lease commencement date	Aug. 01, 2022
Operating lease, option to extend term	7 years
Estimated payments due	$ 35,200,000
Letters of credit	800,000
Maximum reimbursement cost	500,000
Incurred of expenses related to expansion	$ 100,000